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Cell signaling transmits the proliferation of cells in the body. Migration, differentiation and apoptosis are regulated by the interaction between cells, the matrix and nutritional conditions and hormones and other signaling molecules. The transmission of information. The signaling molecules pass from the vasculature in the body The transfer of cells to another tissue cell plays a role. This process is called endocrine; the way of directly acting on neighboring cells without passing through the blood is called paracrine. It is interesting to find that soluble signaling substances secreted by some cells act on the same Harmful cells are called homoparacrine. Interestingly, it is found that soluble signaling substances secreted by certain cells act on the same type of cells, which are called homotypic secretion or homotypic secretion. In addition, the signaling substances secreted by the same cell type act Different reaction proteins are called heterotypic paracrine (hereinafter referred to as paracrine). Signal substances synthesized by the cell itself and acting on the cell itself by binding to its own receptor are called autocrine signal substances. These types of substances exist in the body The way of cell signal transmission, in vitro, under normal conditions with basic medium, there are only two methods of autocrine and homologous secretion .Under low cell density conditions, many mediums cannot effectively inoculate cells, partly due to the dilution of one or more autocrine or homologous secretion signal substances, which is why conditioned medium or feeder layer should be selected to improve inoculation Efficiency. Function-specific cell survival, proliferation maintenance, and differentiation induction require paracrine and endocrine signaling molecules, so it is necessary to add appropriate signaling substances to the differentiation medium. However, their function is not only two or more molecules The synergy is so simple (McCormick and Freshney, 2000). Therefore, it is necessary to supplement the exogenous paracrine substances to promote cell interactions. At the same time, we must consider the phenotype of the cells, the synthesis of substances and the time of substance synthesis due to the interaction. At least, the secretion of heterogeneous substances by cultured cells may be a simple method to provide corresponding signal molecules for the formation of a suitable matrix microenvironment. Now we can analyze the interaction between signal molecules and cells by blocking antibodies and antisense RNA technology. .
October 27, 2020