Japanese research found that the switch of neural circuit development Japanese researchers reported in the online version of the latest issue of "Development Cell" in the United States that the neurotransmitter serotonin in the baby's brain exerts the same function as a "switch" on the development of neural circuits effect. After the serotonin concentration changes, the neural circuit begins to develop.

Nerve conduction velocity is a diagnostic technique used to assess peripheral nerve conduction function, and usually includes the measurement of motor nerve conduction velocity (MCV) and sensory nerve conduction velocity (SCV).

(1) MCV measurement: ① Electrode placement: The stimulation electrode is placed on the nerve trunk, the recording electrode is placed on the abdominal muscle, the reference electrode is placed on the tendon; the ground wire is placed between the stimulation electrode and the recording electrode. ② Calculation of MCV: Super-stimulate the distal and proximal ends of the nerve trunk. Two compound muscle action potentials (CMAP) can be recorded on the innervated muscle, and the different incubation periods are measured. The distance between the proximal ends divided by the difference in latency between the two points is the conduction velocity of the nerve. The calculation formula is: nerve conduction velocity (m / s) = distance between two points (cm) × 10 / latency difference between two points (ms). The measurement of amplitude is usually taken as the peak-to-peak value.

(2) SCV measurement: â‘  electrode placement: stimulate the end of the finger or toe and collect it in the proximal nerve trunk (cis method), or stimulate the nerve and collect it in the end of the finger or toe in the reverse direction (reverse method); The ground wire is fixed between the stimulation electrode and the recording electrode. â‘¡ SCV calculation: record the incubation period and sensory nerve action protential (SNAP), and divide the distance between the stimulation electrode and the recording electrode by the incubation period as SCV.

Researchers at institutions such as Kanazawa University and Tokyo University found that the premature laboratory rats developed neural circuits that process beard tactile information earlier than normal laboratory mice. The research team examined the cerebrospinal fluid of these premature rats and found that serotonin began to decrease sharply 5 days after birth. The researchers subsequently increased the concentration of serotonin in premature rats and found that their neural circuits no longer continue to develop.

The research team also found that the same mechanism exists for neural circuits that process visual information. Serotonin concentration decreases and neural circuits begin to develop. Serotonin concentration increases, and neural circuits stop developing.

The research team leader, Kanazawa University professor Kawasaki Yosaki said: "This discovery clarifies part of the mechanism of birth and brain development and helps to understand why premature birth causes developmental disorders."

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