I. INTRODUCTION In the world in the early 1950s, the "bubble-blowing" molding process method in the world began. The use of foreign pharmaceutical polyolefin plastic bottles (hdpe, pp) was earlier than the seventies. The related equipment research manufacturers are wheaton, jomar, battenfeld, bekum, asb, aigo, and unilay milacron of Italy. The main models are one-step three stations, the vertical screw structure in the United States and Japan, Germany, Italy uses a horizontal screw structure.
Collapsible Box With Corner Folding
With the continuous development of people's manufacturing and industry, paper box design and production gradually improved, but also led to the increasing number of folding style. Collapsible box with corner folding is one of the popular folding style, it just need 4 double adhesives to make the box set up. Collapsible box has the advantages of low processing
cost and convenient storage and transportation.
Collapsible Box With Corner Folding Collapsible Box With Corner Folding,Folding Box With Adhesive,Collapsible Flat Packed Box,Custom Folding Type Paper Box Huizhou Cailang Printing Products Co.,Ltd. , https://www.paperboxs.nl
Second, medicinal plastic bottles commonly used production process and raw material selection
1, production process
(1) Extrusion-blow moulding is also called hollow extrusion blow molding. The extruder extrudes the hollow tube continuously, cutting it into small pieces with scissors (manual) or cutting device (automatic), and moving it into a blow-molding mold and blow-molded.
Advantages: Simple equipment, low investment, low cost and price.
Disadvantages: The bottle mouth is uneven and the seal is poor. The raw material is usually ldpe, the barrier performance is much lower than hdpe/pp, and the shelf life of the charge is short.
(2) Two-step method "note-blowing" two steps injection-blow moulding. "Injection, blow molding" is performed separately by two independent machines, commonly known as "two-step method." The first step: injection molding a tube from an ordinary injection molding machine. The bottle head (bottle, thread) has been formed; the second step: manually put the tube on a honeycomb heater or automatic heating belt Heat the thermostat, then move it to the blowing machine and blow it with compressed air.
Advantages: The equipment is simpler and the investment is less. The bottle mouth is flat and well sealed. Variety development is fast, mold cost is lower, cost price is medium and low.
Disadvantages: Injection tube blank and blow molding step by step, easy to transmit pollution, bacteria inspection is difficult to guarantee, the same product is poor, not suitable for mass production.
(3) One step injection-blow moulding. "Injection, blow molding" is done on the same machine. According to different models, it is divided into three stations and two stations "note-blowing". The three stations of the "injection-blowing" machine in the three stations are distributed in an equilateral triangle with an angle of 120°. The first station is the injection molding station, the second station is the blow molding station, and the third station For removing the bottle station. The three stations can be operated at the same time, with high production efficiency, short cycle, and can be automatically counted and packaged with the conveyor belt to truly achieve "no contact" with the manpower in the whole process of production of medicinal plastic bottles to ensure that the products are clean and hygienic. The two stations of the “injection-blowing†plastic machine can be arranged up, down or in front of and behind; the first station is the injection molding station, and the second station is the blow molding station; there is only one dedicated removal and cooling Stations, so it is difficult to achieve automatic counting packaging (usually bulk manual counting). In addition, the production cycle is longer and the production efficiency is lower than the three stations.
Advantages: high degree of automation, high production capacity. The bottle mouth has a high level of smoothness and sealing is excellent. Use hdpe/pp raw materials, uniform bottle wall, excellent barrier performance, long shelf life of the charge. At present, the domestic standard pharmaceutical companies have basically adopted a one-step "injection" process equipment, of which the main "three-station" structure.
Disadvantages: Large equipment investment, complex molds, and high system configuration requirements. Not very suitable for small varieties and small batch production. However, mass production can achieve high quality and low cost with good economic returns.
2 commonly used plastic raw materials solid drug packaging should use hdpe / pp, one-step "injection - blowing" production of polyolefin plastic containers; liquid drug filling should be used
Pet/pp "Pick-pull-blow" process for the production of plastic containers.
(3) Colorant and processing aids The bottle colorant is usually titanium dioxide tio2 (anatitanic or rutile), with tio2 content ≥98%wt and adding amount 1.0~1.5%wt. Common processing aids include lubricants, zinc stearate and polyethylene waxes. All are white powders, and the addition amount is 0.1 to 1% wt.
In recent years, in order to meet the purification requirements of gmp and 100,000 grades, tio2, zinc stearate, polyethylene wax and ldpe (high m•i) are generally mixed together to make a concentrated masterbatch, which can greatly reduce the dust pollution during the production process. . Typical tio2 color masterbatch formulations are as follows: tio2 (special grade) 60%? Zinc stearate 8%? Polyethylene wax 10%? ldpe 22% For solid drug packaging hdpe, pp is a more appropriate material, with excellent resistance Water vapor permeability can effectively prevent the absorption and deterioration of drugs. However, it should be used with caution for drugs that are susceptible to oxidative deterioration. Ldpe has very poor oxygen barrier properties and is not suitable for the production of medicinal plastic bottles, and it cannot be filled with drugs with longer storage periods. Pet has excellent barrier properties against water and oxygen, and has a transparent appearance. It is ideal for filling liquid medicines (syrups, oral liquids).
Third, pharmaceutical plastic containers "Note - Blow" molding equipment and mold structure include: injection mold (primary mold), blow mold (molding mold), mold core rod (a total of three groups), hot runner, sub nozzle, off Bottle card board, core rod holder composed of several parts. Mold materials, thermal expansion coefficient, surface finish, processing technology and precision, design level, and debugging experience, especially the control of the injection mold temperature, have an impact on the final product quality of the vial.
Fourth, the system design system design and supporting devices on the "injection - blowing" pipeline efficiency should attach great importance to.
In addition to the selection of reliable "injection-blowing" molding machines and quality-accurate "injection-blow" molds, pharmaceutical plastic bottle manufacturers must systematically plan the corresponding gmp specifications and process flow. The main contents include:
1. Central air conditioning system (
Gmp standard workshop, 100,000 purification, gb/t 16292-16294-1996)
The main indicators: cleanliness of 100,000, three filters (fine, medium and high), top send side way.
Number of air changes ≥ 20 times / hr 〓 temperature t = 26 ~ 28 °C
2, chilled water system temperature t = 5 ° ~ 15 °, pressure p ≥ 0.2mpa, flow q ≥ rating
3, cooling water system temperature t ≤ 28 °, pressure p ≥ 0.2mpa, flow q ≥ rating? Spray, circulation system
4, compressed air system pressure p ≥ 1.0mpa, flow q ≥ calibration, configuration regulator tank, freeze dryer, two filter (40μ, 5μ), automatic drainage valve, compressed air temperature 65 ° <20 °C.
5, mold temperature controller water medium mold temperature machine: operating temperature tmax ≥ 120 °C, p ≥ 0.4mpa, microprocessor or pid control;
Oil medium mould temperature machine: working temperature tmax=30-300°C, p≥0.2mpa, pid or one-position control instrument. Suggestion: The production of medicinal plastic bottles use water medium mould temperature machine to ensure the quality of the medicine bottle and prevent the oil medium. Leakage of pollution.
6. Mixing, feeding, and comminution equipment can be controlled in time (timer), if the length is too short or short, the best mixing effect cannot be achieved.
Feeding method is recommended to use top-level feeding, or automatic vacuum feeding. However, it is recommended to use concentrated masterbatch to prevent excessive dust pollution in the workshop.
The grinder should use low-noise and high-efficiency rotary cutters (mainly used for crushing the injection path of the bottle cap and a small amount of waste bottles), and the amount of recycled material should be reasonably appropriate (less than 15% wt) to prevent repeated cycle degradation. performance. Different grades of raw materials must be processed separately (usually bottle resin
m·i ≤ 1.0, cap resin m·i>5), cannot be mixed arbitrarily.
Fifth, according to its specific performance, pharmaceutical plastic bottle production should be:
1. The “injection-blowing†process is selected to ensure the smoothness, high density of the bottle mouth, and the excellent sealing and penetrating performance, so as to ensure the stability of the charge and extend the storage shelf life.
2. One-step three-position "injection-blowing" molding machine and precision molds are used to ensure product accuracy, so as to achieve high quality, high output, high efficiency, low cost, and fast return on investment.
3. System design (gmp, process flow, chilled water system, cooling water system, compressed air refrigeration purification system, electrical system, auxiliary engine) is a very important link, and it is also a necessary condition for stable production and development of pharmaceutical companies. 
August 28, 2019