The rate of obesity is rising among adults and adolescents in the United States and other developed countries. Obesity increases the risk of type 2 diabetes and cardiovascular disease. A better understanding of the growth and expansion of adipose tissue can lead to improved treatments and preventive measures for obesity and type 2 diabetes. Previous studies have shown that fat formation can properly store intracellular fat so that it does not accumulate at high levels in the blood, and therefore plays an important role in maintaining healthy fat homeostasis. Current research suggests that the body's response to stress may prevent the development of fat cells, which may be more harmful than obesity and/or high blood lipid levels. This process is aborted due to a new discovery signal transduction from an adenosine receptor, the A2b adenosine receptor (A2bAR), to a stem cell factor called KLF4, which regulates stem cell maintenance. When A2bAR is expressed, KLF4 levels are enhanced, resulting in inhibition of differentiation of adipose stem cells. The correlation between these two factors can lead to disruption of fat cell development, which can lead to problems of fat storage in the cells and into the bloodstream. Most studies were conducted in a laboratory model, and the team also found that A2bAR activation inhibits adipogenesis in human primary preadipocyte culture systems. Finally, analysis of adipose tissue in obese individuals showed a strong correlation between A2bAR and KLF4 expression in subcutaneous and visceral body fat. Katya Ravid, professor of medical and biochemistry at BUSM and director of the Interdisciplinary Biomedical Research Center at Evans, led the study. He pointed out: "It seems counterintuitive, but for normal function, our body needs adipose tissue, for this purpose Certain biochemical cellular processes are necessary. Our research suggests that dysfunction caused by stress or inflammation disrupts the development of adipose tissue, which may have adverse effects on processes that rely on proper fat cell balance. †The study is part of a major study being conducted at Ravid Laboratories to examine the differentiation of bone marrow and tissue stem cells and the role of adenosine receptors in this process. Tube Clamp,32Mm Chrome Pipe Holders,5 Way 32Mm Tube Connectors,32Mm Chrome Tube Clamp JOKER UNO LIMITED , https://www.jokeruno.com
April 15, 2021