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1 Introduction Editor α1-MG is a glycoprotein synthesized from the liver and lymphocytes of the human body with a molecular weight of approximately 33,000 Daltons. It consists of 167 amino acids and cross-reacts with epitopes such as human leukocyte antigens HLA-A 11, HLA-B20 and HLA-51. α1-MG is widely present on various body fluids and lymphocyte membrane surfaces in human body. α1-MG in blood exists in two forms, namely, free α1-MG and α1-MG (α1MG-1gA) which binds to IgA. Under normal circumstances, α1MG-1gA accounts for about 40% to 70% of the total α1-MG in the blood, and the level of immunoglobulin in the blood has an effect on the ratio between α1-MG and α1MG-1gA. Free α1-MG in the blood can pass through the glomerular filtration membrane, 95%-99% in the renal proximal convoluted tubules reabsorbed and metabolized, only a small amount of excretion from the terminal urine; while the combined α1-MG can not pass the kidney The pellet has a concentration of zero in the urine. It is generally believed that the reasons for the increase of α1-MG in serum and urine are: 1 renal tubular reabsorption and decreased ability to metabolize α1-MG; 2 impaired glomerular filtration; 3 excessive synthesis in vivo; 4 lymphocyte destruction freed. Based on the above 1, 2 points and a large number of clinical experimental studies, it is generally believed that the determination of α1-MG in serum and urine can be used as a sensitive indicator to reflect the impairment of renal tubular reabsorption, and to some extent It is also superior to β2-microglobulin. The α1-MG values ​​determined by different methods are different, and the results of the same method measured under different laboratory conditions are similar. The serum α1-MG concentration not only has gender differences, but also has different ages. It is known that the content of α1-MG in umbilical cord blood of infants is higher than that of normal adults, which may be related to the relatively high lymphocyte content in children compared with normal people. 2 reference value editing radioimmunoassay: 10 ~ 30mg / L. (attached: urine content: 0.48 ~ 4.24mg / L). 3 clinical significance of editing 1, elevated: (1) renal insufficiency caused by various kidney diseases, such as early glomerular injury, primary glomerulonephritis, interstitial nephritis, diabetic nephropathy, lupus kidney, acute and chronic kidney Functional failure, etc.), this test is an indicator for evaluating renal function. (2) Also seen in IgA type myeloma, liver cancer and the like. 2, lower: suggest severe liver damage, seen in patients with liver disease. Elisa kit, elisa kit, Shanghai elisa test, SOD kit, IgG kit, IgM kit, WB test, immunohistochemistry, radioimmunoassay, GIBCO, AMRESCO-Shanghai Xinfan
August 10, 2021